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Jan Marini® Skin Research C-ESTA containing DAE Complex, is a revolutionary concept in anti-aging based on the first topical form of lipid soluble Vitamin C that is stable and able to be absorbed.
C-ESTA is the culmination of years of intensive medical research by Nicholas Perricone, M.D. that has resulted in a patented delivery vehicle, combined with other essential stimulatory factors that can actually address the appearance of sagging and redundant tissue. It is an established fact that Vitamin C plays an essential role in every aspect of the skin's functioning including growth, maintenance and repair of connective tissue, protection from free radical oxidation damage, wound healing, collagen synthesis, and prevention of premature aging.Jan-Marini-New-Look-New-System
Researchers know that wrinkles, sagging skin and age spots do not appear because of a mysterious "aging gene". Rather, skin ages due to cumulative internal and external influences that prevent skin from duplicating and repairing itself perfectly. Flawless perfect skin is not a miracle, but the result of your cellular structure following instructions issued from an infallible set of blue prints. If these instructions could be carried through without interference, medical science has proven that adults would not appear to age after the age of 25. This is not science fiction, but rather actual fact that assures us that our youthful looks would hardly visibly alter throughout our entire adult life.
Collagen constitutes 80% of the dermis. In youth, the collagen structures that support the skin maintain a firm foundation that allows mobility and flexibility, but retains contour and tautness. In addition, water, oxygen and other nutrients travel efficiently through the network to reach the skin's cells and facilitate the excretion of waste products. We must continually remind ourselves that skin aging is not a process associated with a chronological number of the years of life we have lived. More correctly, it is not the years that matter nearly as much as the cumulative exposure to sunlight and other environmental factors. As the skin is subjected to these assaults, it loses its ability to reproduce exact copies of healthy cells, prevent the breakdown of collagen and elastin, repair tissue rapidly, prevent the attack of lipids in cell membranes, and finally, the skin gradually breaks down in general due to free radical damage.

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Considering the critical role Vitamin C plays in every aspect of youthful healthy skin, it is important to remember that humans cannot manufacture Vitamin C. In humans, the total pool of Vitamin C is 1500mg. The average person must have a continuous intake of Vitamin C in order to maintain bodily functions. Skin is especially vulnerable to Vitamin C deficiency because Vitamin C is pulled from the skin to maintain other bodily functions. Physical or emotional stress causes even greater quantity of Vitamin C to be depleted from the skin.

Under clinical laboratory conditions, scientists are able to cause collagen synthesis as well as stimulate skin rejuvenation by transporting Vitamin C into cells. The obstacle to incorporating this into practical application is stabilization and absorption. First, Vitamin C in a topical product degrades or completely loses its potency very easily, especially when exposed to sun or heat. This means that shelf life would be so short that it would be impossible for commercial marketing. Second, it is well recognized that Vitamin C is not readily absorbed through the skin, so even if high concentrations could be stabilized, the effectiveness would be minimal because it would only absorb into the outermost layers of the stratum corneum. Jan Marini® Skin Research has formulated C-ESTA using DAE Complex. This complex is the key to stabilization, absorption, and the ability to produce results beyond any skin care advancement currently available. C-ESTA containing DAE Complex also incorporates a second breakthrough discovery that addresses the appearance of redundant tissue. This technology is part of the DAE Complex and involves research on neurotransmitters. Neurotransmitters are chemicals that allow the brain's messages to be executed into muscle movement. They are also responsible for youthful muscle tone that assists in maintaining firm facial contours. Medical studies have resulted in a revolutionary topical agent that when combined with Vitamin C results in the stimulation of certain neurotransmitters. This process actually addresses areas of facial sagging such as nasolabial folds, the forehead and jaw line jowling.

Medical research has established that vitamin C plays an essential role in every aspect of the skin's functioning, including protection from UV damage and repair of cumulative sun-induced aging factors. It has also been proven that for vitamin C to be present in the skin in medically efficacious levels, it must be transported into cells through topical application. This is a complex technology involving stabilization, optimum skin absorption, adequate levels of activity and documented studies on human tissue substantiating that actual physiological changes are occurring. Confusion and controversy regarding factual data and cosmetic rhetoric are rampant. C-ESTATM containing DAE ComplexTM is the result of 12 years of intensive medical research. These C-ESTA medical facts have been prepared in order to provide accurate and current information regarding C-ESTA's methods of action, its effectiveness as compared to other forms of Vitamin C, and its specific benefits.
This overview is segmented to reflect C-ESTA's two separate modes of action: Ascorbyl Palmitate and DAE Complex.
What is Ascorbyl Palmitate?
Ascorbyl palmitate is a lipid (fat) soluble form of vitamin C. Ascorbyl palmitate maintains all the physiologic activity of vitamin C without the problems that can be associated with ascorbic acid or Lascorbic acid (the common water soluble form of vitamin C).
Ascorbyl palmitate turns on cellular machinery. Human cell cultures, designed to closely simulate the human body, demonstrate this effect. By enhancing the cell's ability to function more effectively, cells are better able to repair any damage and generally "act" in a younger manner.

  • Ascorbyl Palmitate is a neutral pH (non-acidic) molecule. C-ESTA can be applied to any skin type without irritation, as opposed to ascorbic acid whose extremely low acidic pH can create inflammation. C-ESTA does not sting or burn. C-ESTA can be used with glycolic acid, Retin-ATM and after laser resurfacing to assist in the recovery process.

  • Because Ascorbyl Palmitate is fat soluble, it penetrates the skin very rapidly and intersperses in the cell membrane. This affinity with the cell membrane results in tremendous antioxidant benefits and helps to prevent cellular aging such as:

    • Cross linking of collagen

    • Oxidation of proteins

    • Lipid peroxidation

  • Ascorbyl Palmitate acts as an anti-inflammatory. The molecule was tested on several human inflammatory models. Studies demonstrated anti-inflammatory activity when ascorbyl palmitate was applied to psoriasis. Studies also show that ascorbyl palmitate can dramatically decrease UVB induced erythema (sunburn) when applied topically.
    Ascorbyl Palmitate is more active than ascorbic acid. A study conducted at the University of North Carolina compared the efficacy of ascorbic acid and ascorbyl palmitate in the suppression of phorbol ester-induced tumor production (tumors nearly identical to those caused by UV light exposure). This study demonstrated that, while ascorbyl palmitate and ascorbic acid both have tumor suppressing activity, ascorbyl palmitate was 30 times more effective than ascorbic acid at ¼ the dose.

  • Ascorbyl Palmitate is extremely stable. Ascorbyl palmitate is the only vitamin C molecule that will maintain its vitamin C activity for long periods of time. C-ESTA products have a normal two year shelf life.

  • Ascorbyl Palmitate enhances vitamin E activity in the skin.

Because ascorbyl palmitate can reside in the cell membrane, it can regenerate the vitamin E radical on a continuous basis. This is as opposed to ascorbic acid, which only interacts with vitamin E at the interface of the water-soluble and lipid components.

  • Ascorbyl Palmitate has been proven to be physiologically active in human cell cultures.

  • Ascorbyl palmitate shows greater activity than ascorbic acid in fibroblast growth and collagen production.

  • Ascorbyl palmitate shows greater activity than ascorbic acid at lower doses.

  • Ascorbyl Palmitate has better skin absorption and retention than ascorbic acid.

In a study conducted by a division of Proctor and Gamble, skin absorption was compared between ascorbyl palmitate and ascorbic acid. At 2 hours, skin absorption of ascorbyl palmitate was far greater than ascorbic acid. At 24 hours, the amount of ascorbyl palmitate was almost 10 times greater.
Patients and physicians observe the following benefits:

  • Thicker dermis

  • Skin appears more resilient

  • Skin appears plumper and thicker

  • Decrease in the appearance of fine lines and wrinkles

  • Skin appears softer, smoother and more refined

  • Reflective quality of skin is enhanced

  • Lessening of redness due to irritation and inflammation

  • Facial skin appears more even toned

  • Skin that tends toward sensitivity is far less reactive

  • Lessening of the appearance of telangiectasis


  • DAE Complex™ is a powerful "antioxidant cocktail" that acts by stabilizing cell membranes. Stability of the cell membrane is critical to insuring that the cell functions at optimum levels. DAE Complex™ protects and enhances cellular activities.

  • DAE Complex™ contains a proprietary delivery agent that acts as a penetration enhancer, enabling ascorbyl palmitate to penetrate to a more beneficial level.

  • C-ESTA causes a noticeable improvement in the appearance of sagging and redundant skin. The delivery agent in DAE Complex™ is also a precursor of acetyl choline. Acetylcholine is partly responsible for muscle tone. C-ESTA's DAE Complex™ stimulates acetylcholine resulting in the appearance of tighter and firmer skin with more defined facial contours.

Patients and Physicians observe the following benefits:

  • Increased muscle tone

  • Lessening of the nasolabial fold

  • Decreased redundancy of upper eye lids

  • Overall appearance of tighter and more defined facial contours

  • Overall appearance of skin is younger and healthier









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